Gwenpool (Wendolyn Gwen Poole) suddenly finds herself caught in a fracture in space-time. While relaxing at a cafe, she experiences a surreal dimensional split: the environment freezes and fragments, and tiny Deadpool-like creatures materialize—one missing a hand, and one a head—causing chaos until Wade blasts them away. Gwen flees.
Seeking answers, Gwen heads to the Baxter Building, where Reed Richards and the Fantastic Four explain that a massive solar flare has disrupted space-time. An emergency transmission from the Life Foundation suggests something has gone wrong with a sample they were to collect.
Gwen and Johnny Storm are assigned to escort and recover the dangerous sample. They ride out on motorcycles to the facility, only to discover the Life Foundation has suffered casualties and the situation is unstable and ominous.